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Mammalian muscle cells bear a cell-autonomous, heritable memory of their rostrocaudal position.

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Metrics details. In mammals, the hibernating state is characterized by biochemical adjustments, which include metabolic rate depression and a shift in the primary fuel oxidized from carbohydrates to lipids. However, other studies provide contrasting data about the regulation of fuel utilization in skeletal muscles during hibernation. To gain insights into how fuel metabolism is regulated in hibernating bear skeletal muscles, we examined the vastus lateralis proteome and other changes elicited in brown bears during hibernation.
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Louis, Missouri We previously documented a greater than fold rostrocaudal gradient of chloramphenicol acetyltransferase CAT expression in the muscles of adult mice that bear a myosin light chain-CAT transgene: successively more caudal muscles express successively higher levels of CAT. Here we studied the development and maintenance of this positional information in vitro. CAT levels reflect the rostrocaudal positions of the muscles from which the cells are derived in cultures established from adult muscles, in clones derived from individual adult myogenic satellite cells, in cultures prepared from embryonic myoblasts, and in cell lines derived by retrovirus-mediated transfer of an oncogene to satellite cells.
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Radcliffe is considered a pornographic icon, and in particular, an icon of gay bear subculture and its physical aesthetics. Radcliffe was born in Staten Island, New York in Radcliffe was "discovered" in by photographer Chris Nelson.
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