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Previous studies of breast tissue gene expression have demonstrated that the extratumoral microenvironment has substantial variability across individuals, some of which can be attributed to epidemiologic factors. To evaluate how mammographic density MD and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on breast cancer patients from the population-based Polish Women's Breast Cancer Study. Breast cancer cases were classified based on a previously reported, biologically-defined extratumoral gene expression signature with two subtypes: an Active subtype, which is associated with high expression of genes related to fibrosis and wound response, and an Inactive subtype, which has high expression of cellular adhesion genes. MD of the contralateral breast was assessed using pre-treatment mammograms and a quantitative, reliable computer-assisted thresholding method. Breast tissue composition was evaluated based on digital image analysis of tissue sections. By linking novel molecular phenotypes with MD, our results indicate that MD reflects broad transcriptional changes, including changes in both epithelia- and stroma-derived signaling. Molecular profiling of gene expression of breast cancers has demonstrated that tumors are remarkably heterogeneous, which has profound influences on etiological and clinical research 1 , 2.
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Page, who is still alive, was quite a celebrity in her day, until she abruptly disappeared, in , into a life devoted to Jesus. God, she is sure, wants her to be, too. The pictures, she thought, were just for fun. No one actually got hurt—she and the other girls were just horsing around.
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Metrics details. Terminal duct lobular units TDLUs are the primary structures from which breast cancers and their precursors arise. Decreased age-related TDLU involution and elevated mammographic density are both correlated and independently associated with increased breast cancer risk, suggesting that these characteristics of breast parenchyma might be linked to a common factor. Given data suggesting that increased circulating levels of insulin-like growth factors IGFs factors are related to reduced TDLU involution and increased mammographic density, we assessed these relationships using validated quantitative methods in a cross-sectional study of women with benign breast disease.
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