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The aim of this study was to evaluate the influence of the molecular weight mol. Copolymerisation of HPMA, a polymerisable derivative of DOX N-methacryloylglycylphenylalanylleucylglycyl doxorubicin and a newly designed crosslinking agent, N 2 ,N 5 -bis N-methacryloylglycylphenylalanyl-leucylglycyl ornithine methyl ester monomers resulted in novel, high mol. Four conjugates with mol. The results indicated that the half-life in blood and the elimination rate from the tumour were up to 28 times longer and 25 times slower, respectively, for P-DOX mol.
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